Ontology highlight
ABSTRACT:
SUBMITTER: Abualsaud N
PROVIDER: S-EPMC7928066 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Abualsaud Nouran N Caprio Lindsay L Galli Susana S Krawczyk Ewa E Alamri Lamia L Zhu Shiya S Gallicano G Ian GI Kitlinska Joanna J
Frontiers in cell and developmental biology 20210217
Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under various physiological and pathological conditions, including cancer dissemination. Yet, the exact signaling pathways leading to these effects remain unknown. In a pediatric malignancy, neuroblastoma (NB), high NPY release from tumor tissue associates with metastatic disease. Here, we have shown that NPY stimulates NB cell motility and invasiveness and acts as a chemotactic factor for NB cells. We have also iden ...[more]