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Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels.

ABSTRACT: Here we identify a new role for Syndecan (Sdc), the only transmembrane heparan sulphate proteoglycan in Drosophila, in tracheal development. Sdc is required cell autonomously for efficient directed migration and fusion of dorsal branch cells, but not for dorsal branch formation per se. The cytoplasmic domain of Sdc is dispensable, indicating that Sdc does not transduce a signal by itself. Although the branch-specific phenotype of sdc mutants resembles those seen in the absence of Slit/Robo2 signalling, genetic interaction experiments indicate that Sdc also helps to suppress Slit/Robo2 signalling. We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion.

SUBMITTER: Schulz JG

PROVIDER: S-EPMC3185339 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels.

Schulz Joachim G JG Ceulemans Helga H Caussinus Emmanuel E Baietti Maria F MF Affolter Markus M Hassan Bassem A BA David Guido G

EMBO reports 20110930 10

Here we identify a new role for Syndecan (Sdc), the only transmembrane heparan sulphate proteoglycan in Drosophila, in tracheal development. Sdc is required cell autonomously for efficient directed migration and fusion of dorsal branch cells, but not for dorsal branch formation per se. The cytoplasmic domain of Sdc is dispensable, indicating that Sdc does not transduce a signal by itself. Although the branch-specific phenotype of sdc mutants resembles those seen in the absence of Slit/Robo2 sign ...[more]

PMID: 21836636

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