Ontology highlight
ABSTRACT:
SUBMITTER: Hare S
PROVIDER: S-EPMC3185499 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Viruses 20091106 3
Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best-characterized host factors involved in viral replication. Results of intensive studies in several laboratories indicated that the protein serves as a targeting factor for the lentiviral DNA integration machinery, and accounts for the characteristic preference of Lentivirus to integrate within active transcription units. The IN-LEDGF interaction has been put forward as a promising ...[more]