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The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights.

ABSTRACT: Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best-characterized host factors involved in viral replication. Results of intensive studies in several laboratories indicated that the protein serves as a targeting factor for the lentiviral DNA integration machinery, and accounts for the characteristic preference of Lentivirus to integrate within active transcription units. The IN-LEDGF interaction has been put forward as a promising target for antiretroviral drug development and as a potential tool to improve safety of lentiviral vectors for use in gene therapy. Additionally, as a natural ligand of lentiviral IN proteins, LEDGF has been successfully used in structural biology studies of retroviral DNA integration. This review focuses on the structural aspects of the IN-LEDGF interaction and their functional consequences.

SUBMITTER: Hare S

PROVIDER: S-EPMC3185499 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights.

Hare Stephen S Cherepanov Peter P

Viruses 20091106 3

Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best-characterized host factors involved in viral replication. Results of intensive studies in several laboratories indicated that the protein serves as a targeting factor for the lentiviral DNA integration machinery, and accounts for the characteristic preference of Lentivirus to integrate within active transcription units. The IN-LEDGF interaction has been put forward as a promising ...[more]

PMID: 21994569

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