Current and Novel Inhibitors of HIV Protease.
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ABSTRACT:
SUBMITTER: Pokorna J
PROVIDER: S-EPMC3185513 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Current and Novel Inhibitors of HIV Protease.
Pokorná Jana J Machala Ladislav L Rezáčová Pavlína P Konvalinka Jan J
Viruses 20091211 3
The design, development and clinical success of HIV protease inhibitors represent one of the most remarkable achievements of molecular medicine. This review describes all nine currently available FDA-approved protease inhibitors, discusses their pharmacokinetic properties, off-target activities, side-effects, and resistance profiles. The compounds in the various stages of clinical development are also introduced, as well as alternative approaches, aiming at other functional domains of HIV PR. Th ...[more]
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