Ontology highlight
ABSTRACT:
SUBMITTER: Menendez-Arias L
PROVIDER: S-EPMC3185545 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Viruses 20091204 3
Retroviruses are RNA viruses that replicate through a DNA intermediate, in a process catalyzed by the viral reverse transcriptase (RT). Although cellular polymerases and host factors contribute to retroviral mutagenesis, the RT errors play a major role in retroviral mutation. RT mutations that affect the accuracy of the viral polymerase have been identified by in vitro analysis of the fidelity of DNA synthesis, by using enzymological (gel-based) and genetic assays (e.g., M13mp2 lacZ forward muta ...[more]