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Development of viral vectors for use in cardiovascular gene therapy.

ABSTRACT: Cardiovascular disease represents the most common cause of mortality in the developed world but, despite two decades of promising pre-clinical research and numerous clinical trials, cardiovascular gene transfer has so far failed to demonstrate convincing benefits in the clinical setting. In this review we discuss the various targets which may be suitable for cardiovascular gene therapy and the viral vectors which have to date shown the most potential for clinical use. We conclude with a summary of the current state of clinical cardiovascular gene therapy and the key trials which are ongoing.

SUBMITTER: Williams PD

PROVIDER: S-EPMC3185614 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Development of viral vectors for use in cardiovascular gene therapy.

Williams Paul D PD Ranjzad Parisa P Kakar Salik J SJ Kingston Paul A PA

Viruses 20100127 2

Cardiovascular disease represents the most common cause of mortality in the developed world but, despite two decades of promising pre-clinical research and numerous clinical trials, cardiovascular gene transfer has so far failed to demonstrate convincing benefits in the clinical setting. In this review we discuss the various targets which may be suitable for cardiovascular gene therapy and the viral vectors which have to date shown the most potential for clinical use. We conclude with a summary ...[more]

PMID: 21994642

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