Ontology highlight
ABSTRACT:
SUBMITTER: Chatel-Chaix L
PROVIDER: S-EPMC3185733 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Chatel-Chaix Laurent L Baril Martin M Lamarre Daniel D
Viruses 20100820 8
Hepatitis C virus (HCV) infection is a serious and growing threat to human health. The current treatment provides limited efficacy and is poorly tolerated, highlighting the urgent medical need for novel therapeutics. The membrane-targeted NS3 protein in complex with the NS4A comprises a serine protease domain (NS3/4A protease) that is essential for viral polyprotein maturation and contributes to the evasion of the host innate antiviral immunity by HCV. Therefore, the NS3/4A protease represents a ...[more]