Ontology highlight
ABSTRACT:
SUBMITTER: Ali A
PROVIDER: S-EPMC3884027 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Ali Akbar A Aydin Cihan C Gildemeister Reinhold R Romano Keith P KP Cao Hong H Ozen Ayşegül A Soumana Djade D Newton Alicia A Petropoulos Christos J CJ Huang Wei W Schiffer Celia A CA
ACS chemical biology 20130501 7
The hepatitis C virus (HCV) infects an estimated 150 million people worldwide and is the major cause of viral hepatitis, cirrhosis, and liver cancer. The available antiviral therapies, which include PEGylated interferon, ribavirin, and one of the HCV NS3/4A protease inhibitors telaprevir or boceprevir, are ineffective for some patients and cause severe side effects. More potent NS3/4A protease inhibitors are in clinical development, but the long-term effectiveness of these drugs is challenged by ...[more]