Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
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ABSTRACT:
SUBMITTER: Jones KS
PROVIDER: S-EPMC3185769 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
Jones Kathryn S KS Lambert Sophie S Bouttier Manuella M Bénit Laurence L Ruscetti Frank W FW Hermine Olivier O Pique Claudine C
Viruses 20110615 6
The initial step in retroviral infection involves specific interactions between viral envelope proteins (Env) and specific receptors on the surface of target cells. For many years, little was known about the entry receptors for HTLV-1. During this time, however, functional domains of the HTLV-1 Env were identified by analyzing the effects of neutralizing antibodies and specific mutations in Env on HTLV-1 infectivity. More recent studies have revealed that HTLV-1 infectivity involves interactions ...[more]
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