Ontology highlight
ABSTRACT:
SUBMITTER: Weinkove R
PROVIDER: S-EPMC6511336 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Weinkove Robert R George Philip P Dasyam Nathaniel N McLellan Alexander D AD
Clinical & translational immunology 20190511 5
Costimulatory signals are required to achieve robust chimeric antigen receptor (CAR) T cell expansion, function, persistence and antitumor activity. These can be provided by incorporating intracellular signalling domains from one or more T cell costimulatory molecules, such as CD28 or 4-1BB, into the CAR. The selection and positioning of costimulatory domains within a CAR construct influence CAR T cell function and fate, and clinical experience of autologous anti-CD19 CAR T cell therapies sugges ...[more]