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Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions.

ABSTRACT: Guanine (G) rich G(4)T(4)G(4) DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5'-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by pi-pi-stacking interaction exerted by the 5'-residues.

SUBMITTER: Saha S

PROVIDER: S-EPMC3186060 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions.

Saha Sourav S Saha Sourav S Cai Jianfeng J Eiler Daniel D Hamilton Andrew D AD

Chemical communications (Cambridge, England) 20100113 10

Guanine (G) rich G(4)T(4)G(4) DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5'-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by pi-pi-stacking interaction exerted by the 5'-residues. ...[more]

PMID: 20177616

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