Ontology highlight
ABSTRACT:
SUBMITTER: Gupta A
PROVIDER: S-EPMC3856695 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20130719 12
Molecular recognition of DNA quadruplex structures is envisioned to be a strategy for regulating gene expression at the transcriptional level and for in situ analysis of telomere structure and function. The recognition of DNA quadruplexes by peptide nucleic acid (PNA) oligomers is presented here, with a focus on comparing complementary, heteroduplex-forming and homologous, heteroquadruplex-forming PNAs. Surface plasmon resonance and optical spectroscopy experiments demonstrated that the efficacy ...[more]