Ontology highlight
ABSTRACT:
SUBMITTER: Park H
PROVIDER: S-EPMC3186400 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Park HaJeung H Lee Jun Hyuck JH Gouin Edith E Cossart Pascale P Izard Tina T
The Journal of biological chemistry 20110813 40
Pathogenic Rickettsia species cause high morbidity and mortality, especially R. prowazekii, the causative agent of typhus. Like many intracellular pathogens, Rickettsia exploit the cytoskeleton to enter and spread within the host cell. Here we report that the cell surface antigen sca4 of Rickettsia co-localizes with vinculin in cells at sites of focal adhesions in sca4-transfected cells and that sca4 binds to and activates vinculin through two vinculin binding sites (VBSs) that are conserved acr ...[more]