Ontology highlight
ABSTRACT:
SUBMITTER: Verpelli C
PROVIDER: S-EPMC3186429 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20110727 40
Shank3/PROSAP2 gene mutations are associated with cognitive impairment ranging from mental retardation to autism. Shank3 is a large scaffold postsynaptic density protein implicated in dendritic spines and synapse formation; however, its specific functions have not been clearly demonstrated. We have used RNAi to knockdown Shank3 expression in neuronal cultures and showed that this treatment specifically reduced the synaptic expression of the metabotropic glutamate receptor 5 (mGluR5), but did not ...[more]