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Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2.

ABSTRACT: Abstract Cadherins are synthesized with a signal sequence and a proregion that must be removed for optimal adhesive activity. Mutations that prevent processing of cadherins have been implicated in a number of human diseases; thus understanding their processing is critical. In this study, we produced and characterized a number of monoclonal antibodies against the proregion of the desmosomal cadherin, human desmoglein-2, that will facilitate investigations into the processing of this protein.

SUBMITTER: Keim SA

PROVIDER: S-EPMC3186698 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature

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Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2.

Keim Sarah A SA Johnson Keith R KR Wheelock Margaret J MJ Wahl James K JK

Hybridoma (2005) 20080801 4

Abstract Cadherins are synthesized with a signal sequence and a proregion that must be removed for optimal adhesive activity. Mutations that prevent processing of cadherins have been implicated in a number of human diseases; thus understanding their processing is critical. In this study, we produced and characterized a number of monoclonal antibodies against the proregion of the desmosomal cadherin, human desmoglein-2, that will facilitate investigations into the processing of this protein. ...[more]

PMID: 18707543

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