Ontology highlight
ABSTRACT:
SUBMITTER: Jiao X
PROVIDER: S-EPMC7504945 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Jiao Xuyao X Smith Sarah S Stack Gabrielle G Liang Qi Q Bradley Allan A Kellam Paul P Galán Jorge E JE
Infection and immunity 20200918 10
Typhoid toxin is a virulence factor of <i>Salmonella enterica</i> serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5 architecture with two active subunits, the ADP ribosyl transferase PltA and the DNase CdtB, linked to a pentameric B subunit, which is alternatively made of PltB or PltC. Here, we describe the generation and characterization of typhoid toxin-neutralizing human monoclonal antibodies ...[more]