Ontology highlight
ABSTRACT:
SUBMITTER: Barreto L
PROVIDER: S-EPMC3187046 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Barreto Lina L Canadell David D Petrezsélyová Silvia S Navarrete Clara C Maresová Lydie L Peréz-Valle Jorge J Herrera Rito R Olier Iván I Giraldo Jesús J Sychrová Hana H Yenush Lynne L Ramos José J Ariño Joaquín J
Eukaryotic cell 20110701 9
Potassium homeostasis is crucial for living cells. In the yeast Saccharomyces cerevisiae, the uptake of potassium is driven by the electrochemical gradient generated by the Pma1 H(+)-ATPase, and this process represents a major consumer of the gradient. We considered that any mutation resulting in an alteration of the electrochemical gradient could give rise to anomalous sensitivity to any cationic drug independently of its toxicity mechanism. Here, we describe a genomewide screen for mutants tha ...[more]