Ontology highlight
ABSTRACT:
SUBMITTER: Esch BM
PROVIDER: S-EPMC7478846 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Esch Bianca M BM Limar Sergej S Bogdanowski André A Gournas Christos C More Tushar T Sundag Celine C Walter Stefan S Heinisch Jürgen J JJ Ejsing Christer S CS André Bruno B Fröhlich Florian F
PLoS genetics 20200826 8
Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoyl-CoA. Sphingolipid biosynthesis is highly regulated to maintain sphingolipid homeostasis. Even though, serine is an essential component of the sphingolipid biosynthesis pathway, its role in maintaining sphingolipid homeostasis has not been precisely ...[more]