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Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.

ABSTRACT: TORC1-dependent phosphorylation of Saccharomyces cerevisiae Sch9 was dramatically reduced upon exposure to a protonophore or in respiration-incompetent ?(0) cells but not in respiration-incompetent pet mutants, providing important insight into the molecular mechanisms governing interorganellar signaling in general and retrograde signaling in particular.

SUBMITTER: Kawai S 

PROVIDER: S-EPMC3187066 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.

Kawai Shigeyuki S   Urban Jörg J   Piccolis Manuele M   Panchaud Nicolas N   De Virgilio Claudio C   Loewith Robbie R  

Eukaryotic cell 20110812 10

TORC1-dependent phosphorylation of Saccharomyces cerevisiae Sch9 was dramatically reduced upon exposure to a protonophore or in respiration-incompetent ρ(0) cells but not in respiration-incompetent pet mutants, providing important insight into the molecular mechanisms governing interorganellar signaling in general and retrograde signaling in particular. ...[more]

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