Ontology highlight
ABSTRACT:
SUBMITTER: Noyce RS
PROVIDER: S-EPMC3187479 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Journal of virology 20110803 20
We previously found that enveloped virus binding and penetration are necessary to initiate an interferon-independent, IRF3-mediated antiviral response. To investigate whether membrane perturbations that accompany membrane fusion-dependent enveloped-virus entry are necessary and sufficient for antiviral-state induction, we utilized a reovirus fusion-associated small transmembrane (FAST) protein. Membrane disturbances during FAST protein-mediated fusion, in the absence of additional innate immune ...[more]