Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
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ABSTRACT:
SUBMITTER: Sun J
PROVIDER: S-EPMC3188432 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
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Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
Sun Jielin J Zheng Siqun Lilly SL Wiklund Fredrik F Isaacs Sarah D SD Purcell Lina D LD Gao Zhengrong Z Hsu Fang-Chi FC Kim Seong-Tae ST Liu Wennuan W Zhu Yi Y Stattin Pär P Adami Hans-Olov HO Wiley Kathleen E KE Dimitrov Latchezar L Sun Jishan J Li Tao T Turner Aubrey R AR Adams Tamara S TS Adolfsson Jan J Johansson Jan-Erik JE Lowey James J Trock Bruce J BJ Partin Alan W AW Walsh Patrick C PC Trent Jeffrey M JM Duggan David D Carpten John J Chang Bao-Li BL Grönberg Henrik H Isaacs William B WB Xu Jianfeng J
Nature genetics 20080831 10
We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained signi ...[more]
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