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Cumulative evidence for relationships between multiple variants of HNF1B and the risk of prostate and endometrial cancers.

ABSTRACT: BACKGROUND:To provide a synopsis of the current understanding of the association between variants of HNF1B and cancer susceptibility, we conducted a comprehensive research synopsis and meta-analysis to evaluate associations between HNF1B variants and prostate and endometrial cancers. RESULTS:Eighteen studies totaling 34,937 patients and 55,969 controls were eligible for this meta-analysis. Four variants showed a significant association with the risk of individual cancer. Strong significant associations were found between rs4430796 A and the risk of both prostate cancer (OR =?1.247, p =?2.21?×?10-?77) and endometrial cancer (OR =?1.217, p =?8.98?×?10-?16); the AA, AG genotypes also showed strong significant associations with the risk of prostate cancer (OR1?=?1.517, p =?4.46?×?10-?22; OR2?=?1.180, p =?0.002). There was a strong significant association between rs7501939 G and the risk of prostate cancer (OR =?1.201, p =?9.31?×?10-?31). Strong significant association was found between rs11649743 G (OR =?1.138, p =?1.08?×?10-?12), rs3760511 C (OR =?1.214, p =?1.57?×?10-?19) and the prostate cancer risk;the GG, AG genotypes of rs11649743 also showed strong significant associations with the risk of prostate cancer (OR1?=?1.496, p =?3.32?×?10-?6; OR2?=?1.276, p =?7.82?×?10-?6). All the cumulative epidemiological evidence of associations was graded as strong. CONCLUSIONS:Our study summarizes the evidence and helps to reveal that common variants of HNF1B are associated with risk of prostate and endometrial cancer.

SUBMITTER: Tong Y

PROVIDER: S-EPMC6062884 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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