Ontology highlight
ABSTRACT:
SUBMITTER: Townsend D
PROVIDER: S-EPMC3188736 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Townsend DeWayne D Daly Michael M Chamberlain Jeffrey S JS Metzger Joseph M JM
Molecular therapy : the journal of the American Society of Gene Therapy 20110705 10
The aging-related decline in cardiac function is an important public health problem. The molecular basis of age-dependent loss of cardiac function is largely unknown and there are no effective therapies addressing this important form of heart disease. This study evaluates the role of the cytoskeletal protein dystrophin in the process of normal cardiac aging. Here, we show that the cytoskeletal protein dystrophin in the hearts of old mice is significantly decreased to a level of 36% that of young ...[more]