Ontology highlight
ABSTRACT:
SUBMITTER: Su RJ
PROVIDER: S-EPMC3188741 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Su Rui-Jun RJ Epp Angela A Feng Junli J Roy Jackie J Latchman Yvette Y Wu Xiaoping X Bolgiano Doug D Josephson Neil C NC
Molecular therapy : the journal of the American Society of Gene Therapy 20110719 10
Current methods for eradicating clinically significant inhibitory antibodies to human factor VIII (hFVIII) in patients with hemophilia A rely on repeated delivery of high doses of factor concentrates for a minimum of many months. We hypothesize that tolerance can be induced more efficiently and reliably through hFVIII antigen presentation by tolerogenic dendritic cells (tDCs). In this study, we generated tDCs from hemophilia A mice and modified them with a foamy virus vector expressing a bioengi ...[more]