Ontology highlight
ABSTRACT:
SUBMITTER: Hester ME
PROVIDER: S-EPMC3188742 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Hester Mark E ME Murtha Matthew J MJ Song SungWon S Rao Meghan M Miranda Carlos J CJ Meyer Kathrin K Tian Jinbin J Boulting Gabriella G Schaffer David V DV Zhu Michael X MX Pfaff Samuel L SL Gage Fred H FH Kaspar Brian K BK
Molecular therapy : the journal of the American Society of Gene Therapy 20110719 10
Stem cell-derived motor neurons (MNs) are increasingly utilized for modeling disease in vitro and for developing cellular replacement strategies for spinal cord injury and diseases such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). Human embryonic stem cell (hESC) differentiation into MNs, which involves retinoic acid (RA) and activation of the sonic hedgehog (SHH) pathway is inefficient and requires up to 60 days to develop MNs with electrophysiological properties. T ...[more]