Post-translational regulation of signaling mucins.
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ABSTRACT:
SUBMITTER: Cullen PJ
PROVIDER: S-EPMC3189326 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Post-translational regulation of signaling mucins.
Current opinion in structural biology 20110831 5
Signaling mucins are large transmembrane glycoproteins that regulate signal transduction pathways. Recent advances have shown that two major types of post-translational modifications, protein glycosylation and proteolytic processing, play important and unexpected roles in regulating signaling mucin function. New O-glycosyltransferases and proteases have been identified, and the structure of the domain that undergoes auto-proteolysis has been solved. A picture is beginning to emerge where specifi ...[more]
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