Ontology highlight
ABSTRACT:
SUBMITTER: Banks CJ
PROVIDER: S-EPMC6658992 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Redox biology 20190706
SOD1 is commonly known for its ROS scavenging activity, but recent work has uncovered additional roles in modulating metabolism, maintaining redox balance, and regulating transcription. This new paradigm of expanded SOD1 function raises questions regarding the regulation of SOD1 and the cellular partitioning of its biological roles. Despite decades of research on SOD1, much of which focuses on its pathogenic role in amyotrophic lateral sclerosis, relatively little is known about its regulation b ...[more]