Ontology highlight
ABSTRACT:
SUBMITTER: Sommer G
PROVIDER: S-EPMC3189910 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Sommer Gunhild G Rossa Carlos C Chi Angela C AC Neville Brad W BW Heise Tilman T
PloS one 20111010 10
The 5-year survival rate for oral cavity cancer is poorer than for breast, colon or prostate cancer, and has improved only slightly in the last three decades. Hence, new therapeutic strategies are urgently needed. Here we demonstrate by tissue micro array analysis for the first time that RNA-binding protein La is significantly overexpressed in oral squamous cell carcinoma (SCC). Within this study we therefore addressed the question whether siRNA-mediated depletion of the La protein may interfere ...[more]