NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.
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ABSTRACT:
SUBMITTER: Tse HM
PROVIDER: S-EPMC3190397 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.
Tse Hubert M HM Thayer Terri C TC Steele Chad C Cuda Carla M CM Morel Laurence L Piganelli Jon D JD Mathews Clayton E CE
Journal of immunology (Baltimore, Md. : 1950) 20100929 9
Reactive oxygen species are used by the immune system to eliminate infections; however, they may also serve as signaling intermediates to coordinate the efforts of the innate and adaptive immune systems. In this study, we show that by eliminating macrophage and T cell superoxide production through the NADPH oxidase (NOX), T cell polarization was altered. After stimulation with immobilized anti-CD3 and anti-CD28 or priming recall, T cells from NOX-deficient mice exhibited a skewed Th17 phenotype, ...[more]
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