Ontology highlight
ABSTRACT:
SUBMITTER: Eckhard U
PROVIDER: S-EPMC3191118 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Eckhard Ulrich U Schönauer Esther E Nüss Dorota D Brandstetter Hans H
Nature structural & molecular biology 20110925 10
Collagen constitutes one-third of body protein in humans, reflecting its extensive role in health and disease. Of similar importance, therefore, are the idiosyncratic proteases that have evolved for collagen remodeling. The most efficient collagenases are those that enable clostridial bacteria to colonize their host tissues; but despite intense study, the structural and mechanistic basis of these enzymes has remained elusive. Here we present the crystal structure of collagenase G from Clostridiu ...[more]