Ontology highlight
ABSTRACT:
SUBMITTER: Heras B
PROVIDER: S-EPMC3890832 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Heras Begoña B Totsika Makrina M Peters Kate M KM Paxman Jason J JJ Gee Christine L CL Jarrott Russell J RJ Perugini Matthew A MA Whitten Andrew E AE Schembri Mark A MA
Proceedings of the National Academy of Sciences of the United States of America 20131213 1
Aggregation and biofilm formation are critical mechanisms for bacterial resistance to host immune factors and antibiotics. Autotransporter (AT) proteins, which represent the largest group of outer-membrane and secreted proteins in Gram-negative bacteria, contribute significantly to these phenotypes. Despite their abundance and role in bacterial pathogenesis, most AT proteins have not been structurally characterized, and there is a paucity of detailed information with regard to their mode of acti ...[more]