Dendritic cell dysfunction during primary HIV-1 infection.
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ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC3192192 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Dendritic cell dysfunction during primary HIV-1 infection.
Huang Jinghe J Yang Yue Y Al-Mozaini Maha M Burke Patrick S PS Beamon Jill J Carrington Mary F MF Seiss Katherine K Rychert Jennifer J Rosenberg Eric S ES Lichterfeld Mathias M Yu Xu G XG
The Journal of infectious diseases 20111003 10
Dendritic cells have critical roles for generating and fine-tuning adaptive immune responses and for regulating immune activity through cytokine secretion. In this study, we analyzed functional properties of dendritic cells in primary human immunodeficiency virus type 1 (HIV-1) infection. We found substantial disarray of the functional properties of myeloid and plasmacytoid dendritic cells in acute HIV-1 infection, which included defective antigen-presenting and cytokine secretion properties and ...[more]
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