Ontology highlight
ABSTRACT:
SUBMITTER: Zheng K
PROVIDER: S-EPMC3193255 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Zheng Kang K An Juan Ji JJ Yang Feng F Xu Weifeng W Xu Zhi-Qing David ZQ Wu Jianyoung J Hökfelt Tomas G M TG Fisahn André A Xu Baoji B Lu Bai B
Proceedings of the National Academy of Sciences of the United States of America 20110926 41
Although brain-derived neurotrophic factor (BDNF) is known to regulate circuit development and synaptic plasticity, its exact role in neuronal network activity remains elusive. Using mutant mice (TrkB-PV(-/-)) in which the gene for the BDNF receptor, tyrosine kinase B receptor (trkB), has been specifically deleted in parvalbumin-expressing, fast-spiking GABAergic (PV+) interneurons, we show that TrkB is structurally and functionally important for the integrity of the hippocampal network. The amp ...[more]