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TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus.


ABSTRACT: Although brain-derived neurotrophic factor (BDNF) is known to regulate circuit development and synaptic plasticity, its exact role in neuronal network activity remains elusive. Using mutant mice (TrkB-PV(-/-)) in which the gene for the BDNF receptor, tyrosine kinase B receptor (trkB), has been specifically deleted in parvalbumin-expressing, fast-spiking GABAergic (PV+) interneurons, we show that TrkB is structurally and functionally important for the integrity of the hippocampal network. The amplitude of glutamatergic inputs to PV+ interneurons and the frequency of GABAergic inputs to excitatory pyramidal cells were reduced in the TrkB-PV(-/-) mice. Functionally, rhythmic network activity in the gamma-frequency band (30-80 Hz) was significantly decreased in hippocampal area CA1. This decrease was caused by a desynchronization and overall reduction in frequency of action potentials generated in PV+ interneurons of TrkB-PV(-/-) mice. Our results show that the integration of PV+ interneurons into the hippocampal microcircuit is impaired in TrkB-PV(-/-) mice, resulting in decreased rhythmic network activity in the gamma-frequency band.

SUBMITTER: Zheng K 

PROVIDER: S-EPMC3193255 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus.

Zheng Kang K   An Juan Ji JJ   Yang Feng F   Xu Weifeng W   Xu Zhi-Qing David ZQ   Wu Jianyoung J   Hökfelt Tomas G M TG   Fisahn André A   Xu Baoji B   Lu Bai B  

Proceedings of the National Academy of Sciences of the United States of America 20110926 41


Although brain-derived neurotrophic factor (BDNF) is known to regulate circuit development and synaptic plasticity, its exact role in neuronal network activity remains elusive. Using mutant mice (TrkB-PV(-/-)) in which the gene for the BDNF receptor, tyrosine kinase B receptor (trkB), has been specifically deleted in parvalbumin-expressing, fast-spiking GABAergic (PV+) interneurons, we show that TrkB is structurally and functionally important for the integrity of the hippocampal network. The amp  ...[more]

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