Ontology highlight
ABSTRACT:
SUBMITTER: Lau CG
PROVIDER: S-EPMC8810709 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Lau Chunyue Geoffrey CG Zhang Huiqi H Murthy Venkatesh N VN
Journal of cellular physiology 20210907 1
Signaling by neurotrophins such as the brain-derived neurotrophic factor (BDNF) is known to modulate development of interneurons, but the circuit effects of this modulation remain unclear. Here, we examined the impact of deleting TrkB, a BDNF receptor, in parvalbumin-expressing (PV) interneurons on the balance of excitation and inhibition (E-I) in cortical circuits. In the mouse olfactory cortex, TrkB deletion impairs multiple aspects of PV neuronal function including synaptic excitation, intrin ...[more]