Ontology highlight
ABSTRACT:
SUBMITTER: Bai L
PROVIDER: S-EPMC3193497 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Bai Lin L Deng Xiaoli X Li Juanjuan J Wang Miao M Li Qian Q An Wei W A Deli D Cong Yu-Sheng YS
Cell research 20110329 7
Polymerase I and transcript release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae. Here, we show that PTRF expression is increased in senescent human fibroblasts. Importantly, overexpression of PTRF induced features characteristic of cellular senescence, whereas reduced PTRF expression extended the cellular replicative lifespan. Interestingly, we found that PTRF localized primarily to the nuclei of young and quiescent WI-38 human fibrob ...[more]