From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay.
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ABSTRACT:
SUBMITTER: Kraemer S
PROVIDER: S-EPMC3195687 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay.
Kraemer Stephan S Vaught Jonathan D JD Bock Christopher C Gold Larry L Katilius Evaldas E Keeney Tracy R TR Kim Nancy N Saccomano Nicholas A NA Wilcox Sheri K SK Zichi Dom D Sanders Glenn M GM
PloS one 20111017 10
Recently, we reported a SOMAmer-based, highly multiplexed assay for the purpose of biomarker identification. To enable seamless transition from highly multiplexed biomarker discovery assays to a format suitable and convenient for diagnostic and life-science applications, we developed a streamlined, plate-based version of the assay. The plate-based version of the assay is robust, sensitive (sub-picomolar), rapid, can be highly multiplexed (upwards of 60 analytes), and fully automated. We demonstr ...[more]
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