Ontology highlight
ABSTRACT:
SUBMITTER: Brown JW
PROVIDER: S-EPMC3196028 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Brown Jeffrey W JW Farelli Jeremiah D JD McKnight C James CJ
Journal of molecular biology 20110831 3
Villin headpiece is a small autonomously folding protein that has emerged as a model system for understanding the fundamental tenets governing protein folding. In this communication, we employ NMR and X-ray crystallography to characterize a point mutant, H41F, which retains actin-binding activity, is more thermostable but, interestingly, does not exhibit the partially folded intermediate observed of either wild-type or other similar point mutants. ...[more]