Ontology highlight
ABSTRACT:
SUBMITTER: Harpole KW
PROVIDER: S-EPMC4815346 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Harpole Kyle W KW O'Brien Evan S ES Clark Matthew A MA McKnight C James CJ Vugmeyster Liliya L Wand A Joshua AJ
Protein science : a publication of the Protein Society 20151029 2
The thermostable 36-residue subdomain of the villin headpiece (HP36) is the smallest known cooperatively folding protein. Although the folding and internal dynamics of HP36 and close variants have been extensively studied, there has not been a comprehensive investigation of side-chain motion in this protein. Here, the fast motion of methyl-bearing amino acid side chains is explored over a range of temperatures using site-resolved solution nuclear magnetic resonance deuterium relaxation. The squa ...[more]