Ontology highlight
ABSTRACT:
SUBMITTER: Wissing S
PROVIDER: S-EPMC3196128 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Wissing Silke S Montano Mauricio M Garcia-Perez Jose Luis JL Moran John V JV Greene Warner C WC
The Journal of biological chemistry 20110830 42
Members of the APOBEC3 (A3) family of cytidine deaminase enzymes act as host defense mechanisms limiting both infections by exogenous retroviruses and mobilization of endogenous retrotransposons. Previous studies revealed that the overexpression of some A3 proteins could restrict engineered human Long INterspersed Element-1 (LINE-1 or L1) retrotransposition in HeLa cells. However, whether endogenous A3 proteins play a role in restricting L1 retrotransposition remains largely unexplored. Here, we ...[more]