Ontology highlight
ABSTRACT:
SUBMITTER: Warkocki Z
PROVIDER: S-EPMC6191937 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Warkocki Zbigniew Z Krawczyk Paweł S PS Adamska Dorota D Bijata Krystian K Garcia-Perez Jose L JL Dziembowski Andrzej A
Cell 20180816 6
LINE-1 retrotransposition is tightly restricted by layers of regulatory control, with epigenetic pathways being the best characterized. Looking at post-transcriptional regulation, we now show that LINE-1 mRNA 3' ends are pervasively uridylated in various human cellular models and in mouse testes. TUT4 and TUT7 uridyltransferases catalyze the modification and function in cooperation with the helicase/RNPase MOV10 to counteract the RNA chaperone activity of the L1-ORF1p retrotransposon protein. Ur ...[more]