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Glycinergic projection neurons of the cerebellum.

ABSTRACT: The cerebellum funnels its entire output through a small number of presumed glutamatergic premotor projection neurons in the deep cerebellar nuclei and GABAergic neurons that feed back to the inferior olive. Here we use transgenic mice selectively expressing green fluorescent protein in glycinergic neurons to demonstrate that many premotor output neurons in the medial cerebellar (fastigial) nuclei are in fact glycinergic, not glutamatergic as previously thought. These neurons exhibit similar firing properties as neighboring glutamatergic neurons and receive direct input from both Purkinje cells and excitatory fibers. Glycinergic fastigial neurons make functional projections to vestibular and reticular neurons in the ipsilateral brainstem, whereas their glutamatergic counterparts project contralaterally. Together, these data suggest that the cerebellum can influence motor outputs via two distinct and complementary pathways.

SUBMITTER: Bagnall MW

PROVIDER: S-EPMC3196611 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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Glycinergic projection neurons of the cerebellum.

Bagnall Martha W MW Zingg Brian B Sakatos Alexandra A Moghadam Setareh H SH Zeilhofer Hanns Ulrich HU du Lac Sascha S

The Journal of neuroscience : the official journal of the Society for Neuroscience 20090801 32

The cerebellum funnels its entire output through a small number of presumed glutamatergic premotor projection neurons in the deep cerebellar nuclei and GABAergic neurons that feed back to the inferior olive. Here we use transgenic mice selectively expressing green fluorescent protein in glycinergic neurons to demonstrate that many premotor output neurons in the medial cerebellar (fastigial) nuclei are in fact glycinergic, not glutamatergic as previously thought. These neurons exhibit similar fir ...[more]

PMID: 19675244

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