Ontology highlight
ABSTRACT:
SUBMITTER: Wan J
PROVIDER: S-EPMC3196668 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Wan Jing J Kim Sungeun S Inlow Mark M Nho Kwangsik K Swaminathan Shanker S Risacher Shannon L SL Fang Shiaofen S Weiner Michael W MW Beg M Faisal MF Wang Lei L Saykin Andrew J AJ Shen Li L
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 20110101 Pt 2
Genetic mapping of hippocampal shape, an under-explored area, has strong potential as a neurodegeneration biomarker for AD and MCI. This study investigates the genetic effects of top candidate single nucleotide polymorphisms (SNPs) on hippocampal shape features as quantitative traits (QTs) in a large cohort. FS+LDDMM was used to segment hippocampal surfaces from MRI scans and shape features were extracted after surface registration. Elastic net (EN) and sparse canonical correlation analysis (SCC ...[more]