Ontology highlight
ABSTRACT:
SUBMITTER: Amini S
PROVIDER: S-EPMC3197603 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Amini Sasan S Hottes Alison K AK Smith Lincoln E LE Tavazoie Saeed S
PLoS pathogens 20111020 10
Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A major outstanding question is the degree to which the biofilm-specific cellular state and its constituent genetic determinants contribute to this hyper-tolerant phenotype. Here, we used genome-wide functional profiling of a complex, heterogeneous mutant population of Pseudomonas aeruginosa MPAO1 in biofilm and planktonic growth conditions with and without tobramycin to systematically quantify the contribu ...[more]