Ontology highlight
ABSTRACT:
SUBMITTER: Meickle T
PROVIDER: S-EPMC3197893 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Meickle Theresa T Gunasekera Sarath P SP Liu Yanxia Y Luesch Hendrik H Paul Valerie J VJ
Bioorganic & medicinal chemistry 20110606 22
NMR-guided fractionation of a non-polar extract of a Florida Keys collection of Lyngbya sp. resulted in the isolation of two novel epimeric cyclic depsipeptides, porpoisamides A (1) and B (2). The planar structures of these compounds were determined using NMR spectroscopic techniques. The absolute configurations of amino and hydroxy acid subunits were assigned by enantioselective HPLC analysis. These compounds showed weak cytotoxicity towards HCT-116 colorectal carcinoma and U2OS osteosarcoma ce ...[more]