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Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp.

ABSTRACT: The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structural features determined for these compounds include a pendent N-acetyl-N-methyl leucine, both E- and Z-dehydrobutyrines, a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genus Lyngbya, which was isolated from a periphyton mat from the Florida Everglades.

SUBMITTER: An T

PROVIDER: S-EPMC2573040 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature

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Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp.

An Tianying T Kumar Thallapuranam Krishnaswamy Suresh TK Wang Minglei M Liu Li L Lay Jackson O JO Liyanage Rohana R Berry John J Gantar Miroslav M Marks Vered V Gawley Robert E RE Rein Kathleen S KS

Journal of natural products 20070414 5

The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structural features determined for these compounds include a pendent N-acetyl-N-methyl leucine, both E- and Z-dehydrobutyrines, a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genus Lyngbya, which was isolated from a peri ...[more]

PMID: 17432902

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