Mapping rare and common causal alleles for complex human diseases.
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ABSTRACT:
SUBMITTER: Raychaudhuri S
PROVIDER: S-EPMC3198013 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Mapping rare and common causal alleles for complex human diseases.
Cell 20110901 1
Advances in genotyping and sequencing technologies have revolutionized the genetics of complex disease by locating rare and common variants that influence an individual's risk for diseases, such as diabetes, cancers, and psychiatric disorders. However, to capitalize on these data for prevention and therapies requires the identification of causal alleles and a mechanistic understanding for how these variants contribute to the disease. After discussing the strategies currently used to map variants ...[more]
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