Ontology highlight
ABSTRACT:
SUBMITTER: Nurnberg ST
PROVIDER: S-EPMC6975560 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nurnberg Sylvia T ST Guerraty Marie A MA Wirka Robert C RC Rao H Shanker HS Pjanic Milos M Norton Scott S Serrano Felipe F Perisic Ljubica L Elwyn Susannah S Pluta John J Zhao Wei W Testa Stephanie S Park YoSon Y Nguyen Trieu T Ko Yi-An YA Wang Ting T Hedin Ulf U Sinha Sanjay S Barash Yoseph Y Brown Christopher D CD Quertermous Thomas T Rader Daniel J DJ
PLoS genetics 20200109 1
Genome-wide association studies have identified multiple novel genomic loci associated with vascular diseases. Many of these loci are common non-coding variants that affect the expression of disease-relevant genes within coronary vascular cells. To identify such genes on a genome-wide level, we performed deep transcriptomic analysis of genotyped primary human coronary artery smooth muscle cells (HCASMCs) and coronary endothelial cells (HCAECs) from the same subjects, including splicing Quantitat ...[more]