Dataset Information

Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women.

ABSTRACT:

Objective

Excess visceral fat accumulation is associated with the metabolic disturbances of obesity. Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat.

Research design and methods

Nine upper-body obese (UBO; waist circumference >88 cm) and six lean (waist circumference <80 cm) women scheduled for elective tubal ligation surgery were studied. VLDL-TG storage in visceral, upper-body subcutaneous (UBSQ), and lower-body subcutaneous (LBSQ) fat were measured with [9,10-(3)H]-triolein-labeled VLDL.

Results

VLDL-TG storage in visceral fat accounted for only ~0.8% of VLDL-TG turnover in UBO and lean women, respectively. A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat. The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots. VLDL-TG fractional storage and VLDL-TG concentration were correlated in UBO women in UBSQ fat (r = 0.68, P = 0.04), whereas an inverse association was observed for lean women in visceral (r = -0.89, P = 0.02) and LBSQ (r = -0.87, P = 0.02) fat.

Conclusions

VLDL-TG storage efficiency is similar in all regional fat depots, and trafficking of VLDL-TG into different adipose tissue depots is similar in UBO and lean women. Postabsorptive VLDL-TG storage is unlikely to be of major importance in the development of preferential upper-body fat distribution in obese women.

SUBMITTER: Sondergaard E

PROVIDER: S-EPMC3198059 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Publications

Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women.

Søndergaard Esben E Nellemann Birgitte B Sørensen Lars P LP Gormsen Lars C LC Gormsen Lars C LC Christiansen Jens S JS Ernst Erik E Dueholm Margit M Nielsen Søren S

Diabetes 20110912 11

<h4>Objective</h4>Excess visceral fat accumulation is associated with the metabolic disturbances of obesity. Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat.<h4>Research design and methods</h4>Nine upper-body obese (UBO; waist circumference >88 cm) and six lean (waist circumference <80 cm) women scheduled for elective tubal ligation surgery were studied. VLDL-TG sto ...[more]

PMID: 21911742

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Dataset Information

Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women.

Objective

Research design and methods

Results

Conclusions

Publications

Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women.

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