Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance.
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ABSTRACT:
SUBMITTER: Jain RA
PROVIDER: S-EPMC3198425 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance.
Jain Roshan A RA Wolman Marc A MA Schmidt Lauren A LA Burgess Harold A HA Granato Michael M
PloS one 20111019 10
Forward genetic screens in vertebrates are powerful tools to generate models relevant to human diseases, including neuropsychiatric disorders. Variability in phenotypic penetrance and expressivity is common in these disorders and behavioral mutant models, making their molecular-genetic mapping a formidable task. Using a 'phenotyping by segregation' strategy, we molecularly map the hypersensitive zebrafish houdini mutant despite its variable phenotypic penetrance, providing a generally applicable ...[more]
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