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Pharmacogenetics and age-related macular degeneration.

ABSTRACT: Pharmacogenetics seeks to explain interpatient variability in response to medications by investigating genotype-phenotype correlations. There is a small but growing body of data regarding the pharmacogenetics of both nonexudative and exudative age-related macular degeneration. Most reported data concern polymorphisms in the complement factor H and age-related maculopathy susceptibility 2 genes. At this time, the data are not consistent and no definite conclusions may be drawn. As clinical trials data continue to accumulate, these relationships may become more apparent.

SUBMITTER: Schwartz SG

PROVIDER: S-EPMC3199209 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Pharmacogenetics and age-related macular degeneration.

Schwartz Stephen G SG Brantley Milam A MA

Journal of ophthalmology 20111020

Pharmacogenetics seeks to explain interpatient variability in response to medications by investigating genotype-phenotype correlations. There is a small but growing body of data regarding the pharmacogenetics of both nonexudative and exudative age-related macular degeneration. Most reported data concern polymorphisms in the complement factor H and age-related maculopathy susceptibility 2 genes. At this time, the data are not consistent and no definite conclusions may be drawn. As clinical trials ...[more]

PMID: 22046503

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